Divergent transcriptomic responses to repeated and single cold exposures in Drosophila melanogaster

first_imgInsects in the field are exposed to multiple bouts of cold, and there is increasing evidence that the fitness consequences of repeated cold exposure differ from the impacts of a single cold exposure. We tested the hypothesis that different kinds of cold exposure (in this case, single short, prolonged and repeated cold exposure) would result in differential gene expression. We exposed 3 day old adult female wild-type Drosophila melanogaster (Diptera: Drosophilidae) to –0.5°C for a single 2 h exposure, a single 10 h exposure, or five 2 h exposures on consecutive days, and extracted RNA after 6 h of recovery. Global gene expression was quantified using an oligonucleotide microarray and validated with real-time PCR using different biological replicates. We identified 76 genes upregulated in response to multiple cold exposure, 69 in response to prolonged cold exposure and 20 genes upregulated in response to a single short cold exposure, with a small amount of overlap between treatments. Three genes – Turandot A, Hephaestus and CG11374 – were upregulated in response to all three cold exposure treatments. Key functional groups upregulated include genes associated with muscle structure and function, the immune response, stress response, carbohydrate metabolism and egg production. We conclude that cold exposure has wide-ranging effects on gene expression in D. melanogaster and that increased duration or frequency of cold exposure has impacts different to those of a single short cold exposure. This has important implications for extrapolating laboratory studies of insect overwintering that are based on only a single cold exposure.last_img read more

Ox Hub moves in

first_imgThe Oxford Hub, the organization that acts as the focal point for the university’s charitable activities and volunteering, is seeking to acquire property on Turl Street to be used as its central venue.The building will be used to “house a cafe-bar-restaurant, hold events, incubate projects, provide training for volunteers, be a venue for like-minded charitably-inclined people to hang out, and a place where students can come to find out more about the issues that really matter to the local, national and international communities.”Although Hannah MacDiarmid, OxHub President, sent out a message earlier in the week saying that the charity group is planning on buying the new venue, it has now been confirmed that they are looking to obtain the lease instead.If OxHub is successful in its bid, the first floor of the venue will be dedicated to catering facilities, providing “high quality, ethically produced, affordable food.”There are plans to include breakfast service, lunch, café service and evening dining and drinking. The rest of the venue space is to be used as “overspill for the cafe, providing informal workspace during the day” which would transition into a lounge bar in the evening.O’Boyle is hoping that the revenue from these catering facilities “would generate the necessary funds” to pay for the lease.“We really do think this will raise awareness of the Hub’s work and hope it will significantly improve town-gown relations by increasing the number of student volunteers involved with our projects and therefore making a positive contribution to the local community. “We’re very excited about the venture so are doing all we can to put a winning bid together.”Students have also expressed their enthusiasm for the idea. Claire Wright, a second-year student at Univ believes that this is “the most exciting Oxford project I’ve heard of yet.”A microwebsite has been set up in order to promote the project, as well as a facebook group.last_img read more

Oteil Burbridge Releases Magical Studio Record “Water In The Desert” [Stream]

first_imgOteil Burbridge‘s long-awaited studio record, Water In The Desert, is here. The album was produced by David Ryan Harris (who spent much of 2017 on the road with John Mayer), and features some of Burbridge’s favorite players, including brother Kofi Burbridge on keys, Lil’ John Roberts and Sean O’Rourke on drums, Mark Rivers and Alfreda Gerald on vocals, Dave Yoke on guitar and Miguel Atwood Ferguson on strings.“I started writing the songs on this record about ten years ago,” says Burbridge, two-time Grammy-winning bassist, in a statement. “They are all songs about love in some way; finding out how to love yourself, hoping that another loved one will love you just as you are, believing in someone when they find it hard to believe in themselves, love gone wrong, or finally finding the “perfect fit.” I feel like every problem we have on earth in some way comes back to the lack of love. That’s really what this record is about.”“Let Oteil Sing” Campaign Brings $4K To The Gorilla Doctors Following Dead & Co’s 2017 Summer TourWith elements of funk, soul, jazz, and beyond, the concept of love is beautifully executed on the 9-track record. Even better, Oteil is bringing the music on the road with him next month for a mini Oteil & Friends tour. During his time off from Dead & Company, the bassist will be joined by JGB keyboardist Melvin Seals, Lettuce/Soulive guitarist Eric Krasno, Furthur guitarist John Kadlecik, Primus/RatDog/Electric Beethoven drummer Jay Lane, former Nth Power and current Trombone Shorty percussionist Weedie Braimah, and vocalist Alfreda Gerald for a 9-date tour this November.While Oteil & Friends were previously slated to perform a sold-out show at Le Poisson Rouge in NYC on November 9, the show was rescheduled for Dead & Company’s appearance at Band Together: Benefit Concert For North Bay Fire Relief.You can purchase Oteil Burbridge’s fantastic new record, Water In The Desert, on iTunes, Apple Music, Amazon, and listen to it below on Spotify:Oteil & Friends 2017 Tour October 31 — The Ardmore Music Hall; PANovember 1 — Pour House; Charleston, SCNovember 2 — Georgia Theatre; Athens, GANovember 3 — Salvage Station; Asheville, NCNovember 4 — Neighborhood Theater; Charlotte, NCNovember 5 — The Lincoln Theatre; Raleigh, NCNovember 6 — Fillmore; Silver Spring, MDNovember 7 — The Rex Theater; Pittsburgh, PANovember 8 — Soundstage; Baltimore, MDlast_img read more

German beer sales suffer as virus restrictions bite

first_imgBERLIN (AP) — Official data show that beer sales in Germany were down 5.5% last year, dragged lower by lengthy closures of bars and restaurants in the coronavirus pandemic. The Federal Statistical Office said Monday that German-based breweries and distributors sold 8.7 billion liters (2.3 billion gallons) of beer last year. German beer sales have been declining for years as a result of health concerns and other factors. They have now fallen 22.3% since 1993. But last year’s drop was unusually sharp, and a month-by-month breakdown pointed to the impact of coronavirus restrictions.last_img

Students consider midterm elections

first_imgJunior Drew Webster said he feels like he’ll pay more attention to politics and voting when he is older. “I know there are elections, but being away at school, I don’t really pay attention to Chicago politics,” junior Drew Webster said. Midterm elections begin tomorrow. Some students said they are politically aware, but they have gotten caught up in school and being away from home. While most said they know there is an upcoming election, some noted they haven’t really thought about the issues. “I’m registered and voted before, but it didn’t even cross my mind [this year],” sophomore Ella Bergmann said. Some students said they have found that being away from their home states doesn’t just remove them from the issues; it makes the process of voting more difficult. Registering to vote with an absentee ballot is different in each state, but most of the deadlines fall in mid-October, according to longdistancevoter.org. “I didn’t vote because I didn’t get all my paperwork done. I wasn’t registered before this,” freshman Rayven Moore said. Early voting is also an option for some students attending school outside their home states. However, not every state offers this and many states require the votes to be cast in specific locations. “I voted early, but there was some drama,” freshman Amy Klopfenstein said. “They didn’t get my registration, so I filled out an emergency registration form so I could vote.” The students who voted were not just looking at the issues; they said also considered candidates and political parties into their decisions. “I wrote in my votes for senate and governor, because I didn’t like either candidate,” Klopfenstein said. “I also voted for a few issues that are important to me.” Other students that voted have kept up on what is going on in their state politics regarding certain issues and are looking forward to see the outcome on Election Day. ” I voted absentee for California,” junior Ryan Geraghty said. “I’m interested to see what happens with [Proposition 19, the ballot proposition for legalizing some marijuana use].” Some students said that while being educated on the issues and candidates is important, the campaign ads candidates run are annoying. While many were home over break, they said seemed to be bombarded with political ads at every turn. “I’ll just be happy to see the campaign ads stop,” Geraghty said. “California’s been called out on the amount of money spent on and the content of the ads. It made me want to vote for a third party just to spite [Democratic gubernatorial candidate Jerry] Brown and [Republican gubernatorial candidate Meg] Whitman.”last_img read more

University announces 3.7 percent tuition increase

first_imgThe University announced undergraduate tuition and fees will increase 3.7 percent for the 2016-17 academic year to $49,685 in a press release Friday.“Average room and board rates of $14,358 will bring total student charges to $64,043,” the release stated. “The percentage increase matches that of last year and is the lowest at Notre Dame in more than a half century.”The increase in 2014, 2013, 2012 and 2011 was 3.8 percent.“The charges were set by the Board of Trustees at its Jan. 29 meeting,” the release stated.According to the 2015-2016 Bulletin of Information, the basic fee for an on-campus student for the academic year ranges from $30,881.50 to $31,137.50 per semester. The tuition and fees for the full-time off-campus student is $23,964.50 per semester for the 2015–2016 academic year.Tags: Board of Trustees, Tuition, tuition increaselast_img read more

Watch Misty Copeland Discuss Starring (& Singing) in On the Town

first_imgHot on the heels of the news that Misty Copeland will be the first African-American female principal dancer at the American Ballet Theatre, came the announcement that she will make her Broadway debut in On the Town. How is she going to fit in headlining the tuner? During her summer holiday from ABT, of course! The hard-working star stopped by CBS This Morning on July 6 and explained that she’d seize the “time to dive into a new challenge.” Copeland also revealed: “I’ve never really sung in front of a big crowd before.” Well, we’re sure it’s something she can learn in twenty-four hours! Check out the interview below and then Copeland in On the Town at the Lyric Theatre August 25 through September 6. View Comments Related Shows On the Town Show Closed This production ended its run on Sept. 6, 2015last_img read more

Transition Is Enveloping U.S. Electricity Sector

first_img FacebookTwitterLinkedInEmailPrint分享Wall Street Journal:The rapid rise of wind and natural gas as sources of electricity is roiling U.S. power markets, forcing more companies to close older generating plants.Wholesale electricity prices are falling near historic lows in parts of the country with competitive power markets, as demand for electricity remains stagnant while newer, less-expensive generating facilities continue to come online.The changing American electricity landscape is pressuring power companies to shed unprofitable plants and reshape their portfolios to favor the new winners. Texas provides a clear example.Citing low gas prices and the proliferation of renewables such as wind and solar, Vistra Energy Corp., a vestige of the former Energy Future Holdings Corp., said it would retire three coal-fired facilities in Texas by early next year and that it plans to merge with independent power producer Dynegy Inc. Exelon Corp., the country’s largest owner of nuclear power plants, placed its Texas subsidiary under bankruptcy protection earlier this month, saying that “historically low power prices within Texas have created challenging market conditions for all power generators.”The average wholesale power price was less than $25 per megawatt hour last year on the grid that coordinates electricity distribution across most of Texas, according to the operator, the Electric Reliability Council of Texas. A decade ago, it was $55.Prices have fallen a similar amount on the PJM Interconnection LLC, the power grid that serves some or all of 13 states, including Pennsylvania and Ohio. A megawatt hour there traded for $29.23 last year, the lowest level since 1999, as far back as the grid’s independent market monitor tracks prices.The price drop at PJM reflects the construction of dozens of new gas-burning power plants, spurred by the abundance of the fuel due to the shale drilling boom. In 2006, 8% of the electricity in PJM was generated by natural gas. In 2016, it was 27%.Weak demand for electricity also has played a role, as Americans purchase more energy-efficient appliances and companies shave power consumption to cut costs. Last year, power demand in PJM grew 0.3% after falling the two previous years.In competitive regions in places like California, wholesale electricity is sold through daily auctions that favor the least-expensive sources of power. The resulting competition—by more power plants to buyers of roughly the same number of megawatts—has most-acutely impacted older coal and nuclear plants, which are struggling to provide competitively priced power. It has even begun to affect older natural-gas-fired facilities that have higher costs.An analysis by investment bank Lazard shows that on an unsubsidized basis and over the lifetime of a facility in North America, it costs about $60 to generate a megawatt hour of electricity using a combined-cycle natural-gas plant, compared with $102 burning coal and nearly $150 using nuclear. By that criteria, Lazard estimates electricity from utility-scale solar and wind facilities is now even cheaper than gas.A megawatt hour of electricity from utility-scale crystalline solar comes in at $49.50 and wind at $45. That metric carries an important caveat, however: It doesn’t factor in that wind and solar are more intermittent producers of power than conventional generation sources, since the sun doesn’t always shine and the wind doesn’t always blow.“It’s too late,” David Schlissel, a director at the Institute for Energy Economics and Financial Analysis, said of the Trump administration’s proposals. “The lesson is if you don’t put your thumb on the scale then gas and renewables will out-compete coal.”More: Electricity Prices Plummet as Gas, Wind Gain Traction and Demand Stalls Transition Is Enveloping U.S. Electricity Sectorlast_img read more

Inside Marketing: Personalized application abandonment process streamlines growth

first_img continue reading » 1SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr Marketing automation has proved to be a revolutionary technology for the financial services industry. The ability to understand, score and engage with members based on their behavior on the organization’s website and online banking, as well as their interactions with the brand via email and social media, sets those credit unions using marketing automation apart from the 69 percent of the competition who are not leveraging this technology.There are various types of sequence and segmented nurturing programs for multi-layered marketing campaigns that can help members and prospects navigate through the sales funnel toward lead conversion. For instance, $3.1 billion Tower Federal Credit Union, Laurel, Maryland, saw a two- to three-times increase in open and conversion rates for emails aimed at leads for loan products after implementing the Act-On marketing automation solution, prompting a sharp rise in loan applications.These loan applications stand out for financial institutions as a form of measurable growth—the more loan applications, the more members and accounts (and potentially more loyalty from existing customers).last_img read more

The CUInsight Experience podcast: Randy Salser – Creating momentum (#92)

first_imgThank you for tuning in to episode 92 of The CUInsight Experience podcast with your host, Randy Smith, co-founder of CUInsight.com. This episode is brought to you by our friends at PSCU. As the nation’s premier payments CUSO, PSCU proudly supports the success of more than 1,500 credit unions.My guest today is Randy Salser, the President of NAFCU Services Corporation. Listen as we talk about credit unions, leadership lessons learned, and life. Randy shares some great stuff on remote work, keeping teams connected, moving fast, and failing fast. Randy discusses how his team at NAFCU Services is holding up during this pandemic, how he has grown as a leader while leading through a global health crisis, and the changes he has seen credit unions makeover the last six months. They are having success with virtual conferences, but he is ready for in-person conferences to resume human interaction.In the leadership and life hacks section, we learn what inspired Randy to take the position at NAFCU Services and how the inspiration has changed over the years. Momentum is something his team has heard him say often, and Randy shares that he always could make hard decisions; he thinks he does it better now though. When he has a day off, he hangs out with his kids and travels around in their RV to his son’s laCrosse tournaments.We learned that Randy wanted to be a professional football player as a child during the rapid-fire questions, but in high school, that changed to an archeologist. Exercise and reading have become his daily routines, and time has become more important. I think you will enjoy this conversation. Stay well and enjoy!Subscribe on: Apple Podcasts, Spotify, Google Play, StitcherBooks mentioned on The CUInsight Experience podcast: Book List How to find Randy:Randy Salser, President of NAFCU [email protected]/nafcuservicesLinkedIn | Twitter | Facebook | Instagram  Show notes from this episode:A big shout-out to our friends at PSCU, an amazing sponsor of The CUInsight Experience podcast. Thank you!Check out all the outstanding work that Randy and his team at NAFCU Services are doing here.Event mentioned: NAFCU Innovation SpotlightShout-out: Daniel WeickenandShout-out: Lisa SchlehuberShout-out: Debra SchwartzShout-out: Pete Hilger and his team at Allied SolutionsShout-out: Dan BergerShout-out: Carrie HuntShout-out: Anthony DemangoneShout-out: Randy’s wife Amy and their childrenShout-out: Jill NowackiAlbum mentioned: Greatest Hits by Lynyrd SkynyrdAlbum mentioned: Straight outta ComptonAlbum mentioned: The ChronicShout-out: John SpenceBook mentioned: Empire of the Summer Moon by S.C. GwynneBook mentioned: Awesomely Simple by John SpencePrevious guests mentioned in this episode: Pete Hilger, Dan Berger, Carrie Hunt, John Spence, Jill Nowacki (episodes 4, 18, 37, 64 & 82) This Episode:[01:56] – Welcome to the show, Randy![02:10] – Randy shares how everyone is holding up at NAFCU Services.[03:35] – How have you grown as a leader with the pandemic?[05:22] – Randy discusses the changes he has seen over the last few months.[07:42] – Randy hopes that in-person conferences will continue soon, but for now, they still have them virtually, but in the future, they may become hybrid.[10:42] – They speak about staying in touch with the new technology when there are no trade shows to go to.[12:26] – What will you be the proudest of your team’s accomplishments in the next year?[13:34] – Randy shares what inspired him to take the position at NAFCU Services.[15:03] – Listen as Randy speaks about how the inspiration has changed over the last seven years.[16:00] – Randy says that momentum is something his team has heard him say over and over.[16:41] – Have you always had the ability to make hard decisions?[17:42] – Not listening to your team is a mistake he made and believes that today’s young leaders.[18:39] – A common myth that Randy wants to debunk is work smarter, not harder.[19:27] – Fail fast and move on is something they taught him early in his career.[20:35] – How have mentors and advice overall been beneficial in your career?[22:12] – Randy discusses what he likes to do to recharge when he has a day off.[23:55] – Randy was a jock in high school, and he got into fights a lot.[24:35] – When he was young, he wanted to be a professional football player, but he wanted to be an archeologist when he got into high school.[25:31] – Since the pandemic, exercise and reading have been his daily routine.[27:05] – What is the best album of all time?[28:26] – Is there a book you think everyone should read?[29:41] – Time has become more important, and negative energy has become less important.[30:31] – When you hear the word success, which is the first person to come to mind?[31:04] – Randy shares some final thoughts for the listeners.[31:43] – Thank you so much for being on the show! This is placeholder text This post is currently collecting data…center_img 2SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr,Randall Smith Randall Smith is the co-founder of CUInsight.com, the host of The CUInsight Experience podcast, and a bit of a wanderlust.As one of the co-founders of CUInsight.com he … Web: www.CUInsight.com Detailslast_img read more